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While semaglutide can sometimes cause or worsen heartburn, this side effect can be managed with simple diet changes, lifestyle tweaks, and over-the-counter medicines

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Similar results were also reported between semaglutide 2.4 mg and endoscopic sleeve gastroplasty and transpyloric shuttle

Oral semaglutide is ideal for those who prefer a non-invasive option and dislike needles

Similarly, a population-based cohort study using Taiwanese claims data did not demonstrate a significant increase in depression risk among GLP-1RAs users compared with non-users.177 Research on mental health outcomes beyond depression, including health-related quality of life and anxiety, suggests potential improvements associated with GLP-1RAs treatment.175177 Some clinical and preclinical studies have indicated the anxiolytic effects of GLP-1RAs