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Additionally, the FOXO4-p53 interaction contributes to the maintenance of senescent cells by activating the transcription of their common target gene, p21cip1, which suppresses apoptosis 36

Semaglutide was specifically associated with a 44% decreased risk of worsening depression and a 38% decreased risk of worsening anxiety

Liebermeister W, Noor E, Flamholz A, Davidi D, Bernhardt J, Milo R (2014) Visual account of protein investment in cellular functions

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Repeated freeze-thaw cycling is a known nucleation trigger for amyloidogenic peptides as well as a general cause of peptide loss