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burgdorferi outer-surface protein A (OspA) in genetically susceptible individuals is associated with treatment-resistant Lyme arthritis, but a relevant autoantigen has not been identified

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E, F, subungual haematoma with homogenous reddish brown to black colour Differential diagnoses could include: melanocytic lesions naevi (moles) lentigo (increased single melanocytes) melanoma in situ melanoma subungal squamous cell carcinoma (SCC) subungual haemorrhage fungal infection systemic illness (including systemic lupus erythematosus, scleroderma) drug-induced pigmentation ethnic-type pigmentation (can often involve multiple digits)