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Gastrointestinal Adverse Events Gastrointestinal (GI) adverse events are the hallmark safety finding with all GLP-1 receptor agonists, reflecting the physiological effects of GLP-1 signaling on gastric motility, gastric emptying, and central appetite regulation

In addition to their significant effectiveness in glycemic control and weight/fat mass reduction, theyve also been shown to decrease the risk of heart disease, heart failure, stroke and kidney disease

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Pharmacotherapy for obesity: a quantitative analysis of four decades of published randomized clinical trials

Neuromodulation devices later added non-drug options