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In patients with obesity, significant weight reduction achieved with GLP-1 therapy has been associated with improvements in sex hormone-binding globulin (SHBG) levels, reductions in free testosterone in women with hyperandrogenism, and normalization of menstrual cycles in some individuals with polycystic ovary syndrome (PCOS)

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Numerous studies have confirmed that effective management of these risk factors can significantly improve disease symptoms and reduce the recurrence and rehospitalization rates of CVD, thereby extending patient life expectancy and improving quality of life

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Gastroenterology 144 (7), 14261437