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Tirzepatide produces average weight loss of approximately 20% to 22.5% at its highest approved dose of 15 mg over 72 weeks

severe abdominal pain, signs of anaphylaxis, or chest pain require immediate emergency attention

85 Dulaglutide 1.5 mg has demonstrated non-inferiority in diabetes control compared to liraglutide 1.8 mg, and comparable weight reduction efficacy to oral SEMA (Orforglipron) 3 mg

Both are manageable

This decline manifests as: Impaired recovery from exercise and injury Decreased lean body mass Increased adiposity Poor sleep quality, particularly reduced slow-wave sleep Decreased skin elasticity and wound healing Reduced immune function Critically, these two hormonal systems do not operate in isolation