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The Glutathione Skin Whitening Agent Faces Multiple Controversies Regulatory and Safety Concerns The main controversy stems from insufficient standardized rules which govern glutathione treatment practices

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Placebo -Skin and Antioxidant Outcomes A published double-blind RCT showed that oral glutathione supplementation at 500mg/day produced measurable improvements in skin luminosity, reduced melanin index, and increased plasma antioxidant capacity versus placebo at 12 weeks

5e), combination group ( P = 0.0327