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Lastly, the systemic effects of GLP-1RAs, such as body weight loss [103] and potential reduction in muscle mass [104], pose significant challenges for elderly individuals with neurodegenerative diseases

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Current Evidence: GLP-1 Effects on Rheumatoid Arthritis Symptoms As of 2025, there is limited direct clinical evidence examining the effects of GLP-1 receptor agonists specifically on rheumatoid arthritis symptoms or disease progression

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