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Though, evidence indicating the connection between co-activator deregulation and developmental disorders is abundant, very few, if any, systemic study deciphers the detailed molecular mechanism

MC1R receptor variants in very fair-skinned individuals are less responsive to melanocortin signaling, requiring more sustained stimulation to switch from pheomelanin to eumelanin production

Taranta A, Elmonem MA, Bellomo F, De Leo E, Boenzi S, Janssen MJ, Jamalpoor A, Cairoli S, Pastore A, De Stefanis C, Colucci M, Rega LR, Giovannoni I, Francalanci P, van den Heuvel LP, Dionisi-Vici C, Goffredo BM, Masereeuw R, Levtchenko E, Emma F (2021) Benefits and toxicity of disulfiram in preclinical models of nephropathic cystinosis

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[DOI] [PubMed] [Google Scholar] 66.Burcham P.C., Harman A.W