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10.4103/ijd.ijd_418_23 212

Blood GSH/GSSG ratio compared to unprotected glutathione

The importance of hepatic glutathione regulation is underscored by its role in protecting against oxidative liver injury across a wide range of pathological exposures

The amount of oxidized glutathione (GSSG) can be calculated by subtracting the reduced glutathione (GSH) from the total GSH

Furthermore, atrophy and inflammation of mucosal surfaces in the gut are documented in experimental TD (82), and high doses of thiamine have been trialed in two studies showing that thiamine reduced fatigue associated with IBD (199, 200)