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Mounting evidence suggests that GLP-1 RAs have benefits beyond reducing blood glucose that include improving kidney function in people living with type 2 diabetes mellitus (T2DM) and chronic kidney disease (CKD), a common microvascular complication of T2DM
Francesco Giorgino, MD, an investigator on the ACHIEVE-5 trial, offered a longer-term perspective on orforgliprons potential in an interview published by Medscape Medical News, noting that its small-molecule structure makes it significantly easier to manufacture than peptide-based GLP-1 drugs
It tackles the root causes of sleep issues, giving a new view on staying healthy
Key points Cardiovascular outcome trials in individuals with type 2 diabetes mellitus demonstrate that glucagon-like peptide 1 (GLP1) receptor (GLP1R) agonists reduce the rates of non-fatal myocardial infarction, non-fatal stroke and cardiovascular death
Mitchell JL, Lyons HS, Walker JK, et al
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