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Most people reach their target maintenance dose by week 12, at which point the full appetite-suppressing and metabolic effects of semaglutide are active

Taking larger doses less frequently creates unpredictable blood-level spikes that increase side effects and reduce tolerability

Comparison with L-arginine, ranitidine and pantoprazole therapy and L-NG-nitro-L-arginine methyl ester worsening

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