tirzepatide less side effects than semaglutide caused roughly half as many patients to stop treatment because of gastrointestinal as semaglutide. In the first major head-to-head obesity trial, GI side effects caused treatment discontinuation in: Tirzepatide Semaglutide vs. Tirzepatide: Which Weight

When you throw in a lack of hydration and poor eating habits, liquid calories play a big role in obesity

The activity of eNOS is tightly regulated by multiple intracellular process including posttranslational modification, phosphorylation and proteinprotein interactions 14,15

Even when you find a solution that works, sometimes side effects and the costs of treatment can make it feel like you are fighting a losing battle

However, whether a protein of such size could infiltrate the bloodbrain barrier to bind GLP-1R and GIPR in the brain, and whether receptors in the brain are important to the therapeutic effect, still need to be elucidated

I did not swear it off