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However, published scientific research has not yet shown this effect definitively

For example, a population-based observational study reported a higher incidence of pancreatitis among obese individuals treated with semaglutide or liraglutide compared with those receiving naltrexonebupropion

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The study, which ended prematurely due to a higher mortality rate in the intensive treatment group, failed to report significant reduction in major cardiovascular events, giving a notion that intensive therapy was associated with significant harm in high risk patients [6]

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