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J Biol Chem 267:2134421348 Wang X, Misawa R, Zielinski MC, Cowen P, Jo J, Periwal V, Ricordi C, Khan A, Szust J, Shen J, Millis JM, Witkowski P, Hara M (2013) Regional differences in islet distribution in the human pancreaspreferential beta-cell loss in the head region in patients with type 2 diabetes

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This extended trial period (versus typical 30-60 day windows) acknowledges that tissue repair processes are gradual and that fair assessment requires adequate time

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Its a direct sign that the factorys internal systems are under serious pressure