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doi: 10.1159/000485089 187 McNeilEMAstellKRRitchieA-MShaveSHoustonDRBakraniaPet al

Introduction This study, conducted by Kern et al., investigates the effects of oral and transdermal glutathione supplementation in children diagnosed with autism spectrum disorders (ASD)

A consistent pattern emerges: evidence is mostly limited to animal studies human studies, where they exist, are small and short-term there are no high-quality trials reflecting real-world use, including combinations, higher doses or long-term administration

Instead, research points to activity across multiple interconnected systems, including modulation of the nitric oxide (NO) system, upregulation of growth factor expression (notably VEGF, EGF, and FGF pathways), promotion of angiogenesis, and activation of the FAK-paxillin signalling pathway involved in cell migration and tissue organisation

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