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Gclc fl/fl mice were described previously 127 and were crossed to Mb1-Cre + expressing mice 46 to obtain the Gclc fl/fl Mb1-cre strain

In particular, aerobic respiration by mitochondria (the powerhouses of the cell) leads to the production of ROS as oxygen is gradually converted into water

Furthermore, ionic strength and the nature of ionic media also affect the acidbase characteristics of glutathione [96]

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Supplementary Figure S3E), indicating that oxidative stress contributes to the toxicity under conditions of severe overdose (Figure 9)