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for example, in sepsis or ischemia-reperfusion injuries, impaired GPx4 allows ferroptosis to contribute to tissue damage, worsening outcomes

Skin Issues: The skin is often referred to as the "third kidney." If the liver is overwhelmed, the body may try to push toxins out through the skin, leading to blemishes or dullness

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Among them, dimethyl biguanide (known as metformin) was selected for clinical development with the suggestive name of Glucophage, which means glucose eater. The other biguanides, phenformin and buformin, were more potent than metformin, however in the late 1970s they were removed in most countries because of their association with lactic acidosis (Kathuria et al., 2021)