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Over the 8 residues spanning P4 to P4, it has 7 of 8 identical to the M pro site at the nsp12/nsp13 junction, with the only mismatch at the highly variable P3 position (Figure 1D), giving a near-perfect match to the M pro consensus

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A few studies have reported that lack of the endogenous antioxidant enzymes correlates to development of colitis and colon cancer, while increased activity of antioxidant enzymes in the colon effectively reduces oxidative stress-induced colonic tissue damage (58)

10.1177/1535370215609695 86 ShiinaA.KanaharaN.SasakiT.OdaY.HashimotoT.HasegawaT.et al (2015)