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In healthy individuals, GIP(3-30)NH 2 infusions inhibit GIP-potentiated glucose-stimulated insulin secretion (75), thereby confirming GIPs role as a potent incretin hormone (16, 87)

TCF7L2 ties to glucose homeostasis and incretin signaling, GLP1R encodes one of tirzepatide's two receptor targets, and FTO and MC4R shape fat mass and satiety

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Understanding that nausea is an expected pharmacological consequence of how Ozempic worksrather than an allergic reactionhelps patients and clinicians manage expectations and develop appropriate coping strategies

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