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GLP-1 receptor activation can reduce neuroinflammation and oxidative stress, and restore insulin signaling, which may compensate for the dysfunctional dopaminergic neurotransmission and motor deficits associated with PD pathogenesis [74, 75]

Central tolerance versus peripheral tolerance Central tolerance occurs in the thymus, where self-reactive T cells are eliminated before they enter circulation

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PathwayMultiomics: an R package for efficient integrative analysis of Multi-Omics datasets with matched or un-matched samples