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Signs that mast cell activation might be involved include: symptoms that persist long after pollen exposure ends, reactions to multiple unrelated triggers (foods, stress, exercise, temperature changes, chemicals), digestive symptoms accompanying respiratory ones, symptoms that seem disproportionate to exposure levels, and symptoms that respond poorly to antihistamines alone

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Hildebrandt MA , Tan W, Tamboli P, Huang M, Ye Y, Lin J, Lee JS, Wood CG, Wu X