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& Orton, S
The patient had previously been treated with tirzepatide but reportedly achieved only moderate weight loss, and Muniyappa advised against bariatric surgery given the patient's age and comorbidities
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A subsequent study identified the compound N-(4-(2-(4-(trifluoromethyl)phenyl)thiazol-4-yl)phenyl)acetamide as a notable SARM1 inhibitor, which demonstrated significant efficacy in a mouse model of CIPN (Fig
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