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Follow a structured routine and educate yourself on what to expect at each stage

doi:10.4103/0028-3886.383862 De Silva V, El-Metwally A, Ernst E, Lewith G, Macfarlane GJ

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However, the work of Watt and Marcus in 1969 was the first to show that Guinea pigs given high doses of PGN developed caecal and large bowel ulcerations