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As outlined above, coronavirus induce production of mito-ROS during infection

Several patients in whom treatment was continued remained off dialysis for up to 18 months after initiation of rhIGF-1 treatment

Although effective, these protocols were lengthy, costly, and at times impracticalespecially for patients needing intermittent therapy, as serial desensitization was required for temporary tolerance for each antibiotic course

doi: 10.1016/j.carres.2008.03.021