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Restoring Facial Volume with Sculptra & Fillers Rapid weight loss can lead to facial volume loss , making the skin appear sunken or tired

The most comprehensive evidence comes from three sources: the Phase 2 trial published in the New England Journal of Medicine , the Phase 3 TRIUMPH-4 trial, and a systematic review and meta-analysis that synthesized data from 878 total participants across three randomized controlled trials

The Phase 3 cardiovascular study (TRIUMPH-3) is specifically designed to look at heart-related outcomes.[4] Long-term safety data, including effects on bone density, lean muscle mass, and post-stop weight regain, will come from the Phase 3 program and post-market studies

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The difference in fat loss between the 8 mg and 12 mg weekly dose groups was approximately 1 percent