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Particularly, it determined the upregulation of ROS-scavenging enzymes, anti-inflammatory cytokines, (IL-10, IL-6 and PPAR ), tight junctions proteins, such as ZO-1, MUC-2, claudin-3, and the downregulation of inflammatory genes (TNF-, IL-1) [14]

The lack of appetite effects means there is no rebound hunger concern when discontinuing, and the absence of hormonal suppression means no post-cycle therapy is required