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This is the trial a regulator needs to see before broad cardiovascular labeling

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When retatrutide binds to GLP-1 receptors, it stimulates insulin release from the pancreas, reduces glucagon secretion, delays gastric emptying, and suppresses appetite through direct signaling to the brain

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Generally, for medications like Wegovy and Zepbound, which are approved for weight management, individuals must have a Body Mass Index (BMI) of 30 kg/m or greater (considered obese), or a BMI of 27 kg/m or greater (considered overweight) along with at least one weight-related comorbidity such as high blood pressure, type 2 diabetes, or high cholesterol