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MSEA (Table 3) linked alanine, ornithine and urea with a significant alteration of urea cycle metabolism (p = 90% of samples, with a significantly reduced quantity in the BPD group ( 0.2, 0.034)

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Additionally, when the effect on HDAC activity was tested, no significant changes were reported ( In breast cancer, SFN resulted in a significant modification of AKR1C1 and NQO1 expression (30), which are known to be altered in the DCIS (4345)

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