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Daily GIP injections led to a decrease in the adipose tissue gene expression levels of pro-inflammatory cytokines, such as Il-1 beta, Il-6, TNF-alpha in wild-type mice, 60 while blood levels of adiponectin, an anti-inflammatory and insulin-sensitizing adipokine, are enhanced

The peptide fragment from Glu 8P to Arg 15P is enriched with polar and charged amino acids and adopts an -helical conformation, which sits above the orthosteric pocket and interacts with the solvent (Fig