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(v) intraperitoneal administration of naltrexone, an opioid receptor antagonist that crosses the bloodbrain barrier (BBB) reduces differences between black and red-haired mice, but administration of methylated naltrexone that does not cross the BBB does not, suggesting the influence on opioid signalling in red-haired mice is a central, not peripheral phenomenon this implicates -MSH balanced opioid receptormediated regulation of central nociception

This complexity is precisely why a one-size-fits-all approach to research protocols often falls short

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