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Medicine (Baltimore) 2018;97:e12086

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The answer is that it really depends, but in my experience, MOST patients are fine to use subcutaneous injection-sized needles

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The consensus guidelines recently elaborated by the American Society of Regional Anesthesia and Pain Medicine, the American Academy of Pain Medicine, and the American Society of Anesthesiologists support the use of KET for chronic pain, but with different degrees of evidence for different conditions and dose ranges (Jevtovic-Todorovic et al., 2001