Whilst clinical trials have shown modest improvements in cholesterol levels amongst patients using Ozempic, these changes appear largely secondary to weight loss rather than direct lipid-lowering effects
They do not, however, address the question of the physiological role of the endogenously released GLP-1 in these mesolimbic areas
As intracellular GSH is exhausted, the GSH synthesis system will be activated accordingly, which would weaken the efficacy of GSH exhaustion-based cancer therapies in long-term treatment (Niu et al., 2021)
WADA has publicly indicated that if usage patterns emerge that suggest performance-enhancing abuse, GLP-1 class medications could move from monitoring to prohibited status before major events like the LA Olympics
With GLP-1s, CGMs, and preventive apps rising fast, metabolism is becoming the new battleground where science, behaviour, adherence and aspiration collide