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85 The next step involves enoyl-CoA hydratase, which hydrates the double bond through the addition of a hydroxyl group to the beta carbon and a proton to the alpha carbon

By age 60, that level has dropped to roughly 80 ng/mL

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Chondrocyte dedifferentiation was majorly characterized as the reduced expression of COL2 and ACAN and enhanced expression of type I collagen and versican ( COL2 expression, but not ACAN ( In addition to dedifferentiation, another consequence of in vitro expansion is replicative senescence, which also significantly influences chondrocyte function