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Key uncertainties include the human translational relevance of the gliopeptide system, the stability and bioavailability of TDN in humans, potential off-target CNS effects, and the consequences of chronically manipulating glial function. To continue investigating TDN and other ODN derivatives, the press release stated that a new biotech company called CoronationBio has licensed the intellectual property from Syracuse University and the University of Pennsylvania and plans to begin human trials in 2026 or 2027.

Results : The result showed a decrease in the expression of IL-6, IL-1, TNF-, and COX-2, all groups given 1.3 bis( p -Hydroxyphenyl)urea and diclofenac sodium compared to the control group CMC sodium 0.5% CMC sodium 0.5%

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