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Zinc is also involved in the production of metallothionein, and a deficiency in zinc can lead to decreased metallothionein production, further exacerbating copper overload

BAL fluid GSSG strongly and positively correlated with ALOX15 expression, with weaker relationships to POSTN and NOS2 expression

Compared to pioglitazone treatment, rosiglitazone increases the risk of AMI and heart failure in type 2 diabetic patients and elderly patients [222,223,224]

Recent studies also suggest that glycemic variabilityfluctuations in glucose levelsmay be as important as mean glycemia in predicting adverse renal outcomes

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