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Encorafenib plus binimetinib versus vemurafenib or encorafenib in patients with BRAF-mutant melanoma (COLUMBUS): a multicentre, open-label, randomised phase 3 trial

Pre-menopausal women: Women are at an increased risk for depleted iron levels because of the hemoglobin that is lost in the blood during menstruation

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Fatigue and energy levels Fatigue is a commonly reported side effect with both medications that rarely appears in the clinical trial headlines but significantly affects quality of life for many researchers