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What they found: Melanotan II is 100 to 1000 more potent than native -MSH in melanocyte assays Cyclization preserves the active conformation longer than linear -MSH Activates all four functional melanocortin receptors (MC1R, MC3R, MC4R, MC5R) In vivo: visible pigmentation of lizard skin within hours, not days as with -MSH Why it matters: This is the foundational publication of Melanotan II

We were impressed by the reduction of hospitalization and hypertensive emergency GLP-1RAs can offer this patient population, but surprised by the lack of significant difference in amputation and revascularization procedures

Automation of the CHARMM General Force Field (CGenFF) II: assignment of bonded parameters and partial atomic charges

Project administration: VD

According to the researchers, patients treated with GLP-1 receptor agonists experienced a lower incidence of knee surgery compared with patients who were not treated with these medications