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Finally, agonist-induced internalization and recycling of a green fluorescent protein (GFP)-tagged human GLP-1R construct expressed in HEK 293 cells was visualized using confocal microscopy (Fig

Ethics declarations Ethics approval and consent to participate Given that this manuscript is a review article and does not involve any direct research on human or animal subjects, ethical approval and consent to participate are not applicable

Even though absolute muscle dropped, the proportion of lean mass to total body weight actually improved by about 3 percentage points, landing around 57.4%

Trial sequential analysis (TSA) was performed to assess if the available information is sufficient to reject this association

Postnatally, the Igf1 ko mice continued to grow poorly, resulting in an adult weight 30% of wild-type and with poor gonadal function and delayed bone development