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, Activation of MC1R with BMS-470539 attenuates neuroinflammation via cAMP/PKA/Nurr1 pathway after neonatal hypoxic-ischemic brain injury in rats, Springer Science and Business Media LLC, Jan

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The neurodegenerative cascade typically originates at the neuromuscular junction and distal axons, characterized by early synaptic dysfunction and axonal degeneration that progresses to neuronal death, ultimately causing neural transmission failure and motor impairment (Luan et al., 2024)

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In the pancreas, GLP-1 binding to its receptor stimulates the proliferation and regeneration of islet -cells and inhibits their apoptosis [10]