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Figure 2shows the detection results of His racemization impurities produced by His coupling during the preparation of Semaglutide in Example 9 and the prior art (Method 1)
Most GLP-1 medications are administered via subcutaneous injection weekly (semaglutide, dulaglutide, exenatide extended-release) or daily (liraglutide), with oral semaglutide (Rybelsus) representing the only currently available oral formulation
C., Rodrguez-Morgade, M
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