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Its primary actions include: Increasing slow-wave (delta) sleep the deepest, most physically restorative sleep stage Modulating corticotropin-releasing hormone (CRH) reducing the HPA axis signalling that keeps cortisol elevated Influencing LH and somatostatin release both relevant to testosterone and growth hormone secretion Antioxidant activity preclinical data suggests DSIP has direct free-radical scavenging properties (3) Thermoregulatory effects potentially lowering basal body temperature in a manner consistent with natural sleep onset The net effect is not sedation

2026 Mar 22;27(6):2876

However, full effects on metabolism and other areas may take 4-6 weeks as it takes time for levels to build up in the body

For example, growth hormone-releasing peptides increase levels of IGF-1, a hormone involved in tissue growth and repair

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