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Tesamorelin is FDAapproved for HIVassociated lipodystrophy, but this combination and its use for general body recomposition are offlabel and nonFDA-approved

It acts via peripheral lipolytic mechanisms rather than by activating the hypothalamic-pituitary axis, making it relevant to investigational protocols in which systemic GH stimulation is undesirable or contraindicated

effects stop when drug stops