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By the first quarter of 2026, tirzepatide had become the most frequently prescribed agent at roughly 4,700 prescriptions per 100,000 patients, and semaglutide had grown to around 3,900 per 100,000

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The relationship between Rybelsus and vision changes is complex: direct ocular toxicity is not established, but semaglutide has been associated with increased diabetic retinopathy complications in patients with pre-existing disease experiencing rapid HbA1c reduction

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