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Beyond appetite regulation, GLP-1 plays a critical role in blood sugar management

Metabolic Support Peptides, such as tirzepatide found in Zepbound, also enhance metabolism and reduce fat storage, supporting increased weight loss results

GIPR antagonism exemplified by AMG 133 (maridebart cafraglutide) pursues the opposite strategy: blocking GIPR in adipose tissue while activating GLP-1R, based on observations that GIP promotes lipid storage in adipocytes under hyperinsulinemic conditions

This review is part of the PlexusDx Education Hub, a resource covering GLP-1 therapies, weight-management protocols, and the genetic variables that influence how any program performs

10.1038/nrclinonc.2017.40 Nat