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These multidimensional factors spanning mitochondrial metabolism, cellular aging, metabolic function, and childhood trauma provided more detailed signatures to predict longitudinal changes in depression severity than each individual factor alone

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The baseline characteristics and risk of bias evaluation for the included studies were summarized in Additional file 1: Tables S2 and S3

These small adjustments may have significant cumulative benefits over time

Comprehensive chromosomal screening (CCS) of all 24 human chromosomes might have discerned significant differences with the number of oocytes that were available for biopsy