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The localization of internalized GLP-1Rs at the Mitochondria-ER interface supports a contactomics framework for understanding bioenergetic restoration

GIP is another hormone that, like GLP-1, is involved in managing blood sugar and energy balance

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With the popularity of GLP-1 agonists ever-increasing and over 150 GLP-1 drug candidates in development [3], the field is continually expanding, most recently into oncology and obesity-related cancers.[4] While most approved GLP-1RAs require subcutaneous injection, substantial work is being undertaken to move toward oral GLP-1 therapies [5], such as Rybelsus which was the first oral GLP-1RA approved by the FDA in 2019

Pharmacology Biochemistry and Behavior, 13 , 53-61