In addition to mimicking GLP-1, tirzepatide mimics another gut hormone called gastric inhibitory polypeptide, or GIP, that scientists believe has a similar effect on the body as GLP-1
Patients using the drugs for type 2 diabetes restarted their original medication at nearly double the rate of those using them for obesity, 23.5 percent versus 14.2 percent
Taking prescription medications (specifically those that impact the liver or immune system)
Best Weight Loss Medication 2026: Complete GLP-1 Comparison Guide Best Weight Loss Medication 2026: Complete GLP-1 Comparison Guide Tirzepatide (Zepbound, Mounjaro) is the most effective weight loss medication in 2026, producing 15-22% average body weight loss in clinical trials, followed closely by semaglutide (Wegovy, Ozempic) with 10-15% average weight loss, with both significantly outperforming all other FDA-approved weight loss medications
ASC35, a next-generation GLP-1R/GIPR dual peptide agonist, also has 41 alpha amino acids and will be submitted as a BLA as well
