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Each group experienced two severe hypoglycemia events, and no cases of diabetic ketoacidosis were reported

In the AWARD-7 trial (which was not a CVOT) performed in T2DM subjects with moderate-to-severe CKD, onceweekly dulaglutide produced glycemic control similar to that achieved with insulin glargine, but showed evidence of reduced decline in eGFR (64)

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2) There are also studies showing that GDH may interfere with the synthesis of amino acid-related neurotransmitters such as glutamate and GABA [19, 20]

An epidemiological study involving more than 1.6 million participants and thus definitely not underpowered showed, in fact, that removing the appendix diminishes the risk of Parkinsons decades later, especially in people from rural areas who may have been more exposed than others to dysbiosis-causing pesticides (Killinger et al., 2018)