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Additionally, there is inhibition of hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase, resulting in decreased cholesterol production, as well as stimulation of acyl-cholesterol acyltransferase (leading to increased cholesterol esterification)

290 , 56965706 (2015) Lpez de Maturana, R., Treece-Birch, J., Abidi, F., Findlay, J

Insulin-like growth factor receptor signaling regulates working memory, mitochondrial metabolism, and amyloid-beta uptake in astrocytes

Therefore, the Glu/Gln cycle plays a key role in maintaining Glu levels in the central nervous system (Haddad et al., 2021)

Conversely, the group with lower MET exhibited a mere 50.9% PFS rate over six months [147]